Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984084 | 0.91 | LMNA (0.49) | LMNACYP11B1CYP11B2GAAMEN1 | |
| SCHEMBL7983304 | 0.88 | LMNA (0.47) | LMNACYP11B1CYP11B2GAAMEN1 | |
| SCHEMBL7977410 | 0.87 | LMNA (0.46) | LMNACYP11B1CYP11B2GAAMEN1 | |
| SCHEMBL7983319 | 0.87 | LMNA (0.46) | LMNACYP11B1CYP11B2GAAMEN1 | |
| SCHEMBL7980734 | 0.87 | LMNA (0.46) | LMNACYP11B1CYP11B2GAAMEN1 | |
| SCHEMBL7978761 | 0.87 | LMNA (0.46) | LMNACYP11B1CYP11B2GAAMEN1 | |
| SCHEMBL7980436 | 0.87 | LMNA (0.46) | LMNACYP11B1CYP11B2GAAMEN1 | |
| SCHEMBL1610107 | 0.73 | MEN1 (0.51) | LMNACYP11B1CYP11B2MEN1ABCC9 | |
| SCHEMBL7977138 | 0.70 | HDAC3 (0.38) | LMNAGAAMEN1ABCC9CYP1A2 | |
| SCHEMBL7980452 | 0.70 | HDAC3 (0.38) | LMNAGAAMEN1ABCC9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300345-B1 | AS ANTIPROLIFERATIVE AGENT | Leo Pharmacuetical Products Ltd. A/S (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-10-09 | — | — | US | disclosed |