Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978761 | 1.00 | LMNA (0.46) | LMNACDK2FLT4HDAC3HDAC4 | |
| SCHEMBL7983319 | 1.00 | LMNA (0.46) | LMNACDK2FLT4HDAC3HDAC4 | |
| SCHEMBL7977410 | 1.00 | LMNA (0.46) | LMNACDK2FLT4HDAC3HDAC4 | |
| SCHEMBL7980734 | 1.00 | LMNA (0.46) | LMNACDK2FLT4HDAC3HDAC4 | |
| SCHEMBL7983304 | 0.96 | LMNA (0.47) | LMNACDK2FLT4HDAC3HDAC4 | |
| SCHEMBL7984084 | 0.93 | LMNA (0.49) | LMNACDK2FLT4CYP11B1CYP11B2 | |
| SCHEMBL7977100 | 0.87 | LMNA (0.44) | LMNACDK2FLT4CYP11B1CYP11B2 | |
| SCHEMBL7977138 | 0.83 | HDAC3 (0.38) | LMNAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7980978 | 0.83 | HDAC3 (0.38) | LMNAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7980452 | 0.83 | HDAC3 (0.38) | LMNAHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300345-B1 | AS ANTIPROLIFERATIVE AGENT | Leo Pharmacuetical Products Ltd. A/S (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-10-09 | — | — | US | disclosed |