Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.55 |
| ▸ | DRD3 | P35462 | 4/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 9/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 13/20 | 0.46 |
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797394 | 0.97 | DRD2 (0.51) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL791763 | 0.88 | HTR7 (0.60) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL797842 | 0.86 | DRD2 (0.55) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL798515 | 0.85 | DRD2 (0.54) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL15064390 | 0.85 | DRD2 (0.51) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL791866 | 0.85 | HTR7 (0.56) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL797688 | 0.84 | DRD2 (0.54) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL15064356 | 0.82 | DRD2 (0.48) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL797243 | 0.82 | DRD2 (0.57) | DRD2DRD3ADRA1ADRD4HTR7 | |
| SCHEMBL791196 | 0.81 | DRD2 (0.67) | DRD2DRD3ADRA1AHTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616440-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | Adamed sp. z o.o. (PL) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035123-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z O.O. (PL) | 2012-03-22 | — | — | WO | disclosed |