Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987426 | 0.89 | PDE4A (0.65) | PDE4AKCNH2 | |
| SCHEMBL7976870 | 0.85 | PDE4A (0.56) | PDE4AKCNH2 | |
| SCHEMBL7379831 | 0.85 | PDE4A (0.58) | PDE4AKCNH2 | |
| SCHEMBL7384382 | 0.84 | PDE4A (0.57) | PDE4AKCNH2 | |
| SCHEMBL7383186 | 0.84 | PDE4A (0.53) | PDE4AKCNH2 | |
| SCHEMBL7994385 | 0.83 | PDE4A (0.53) | PDE4AKCNH2 | |
| SCHEMBL7977065 | 0.82 | LMNA (0.51) | PDE4ALMNA | |
| SCHEMBL7994691 | 0.82 | PDE4A (0.53) | PDE4AKCNH2 | |
| SCHEMBL7392833 | 0.82 | PDE4A (0.54) | PDE4AKCNH2 | |
| SCHEMBL7991272 | 0.82 | LMNA (0.50) | PDE4ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | claimed |
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |