Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977065 | 0.89 | LMNA (0.51) | LMNAALDH1A1PDE4APDE4BPDE4D | |
| SCHEMBL7991282 | 0.83 | LMNA (0.54) | LMNAALDH1A1PDE4APDE4BPDE4D | |
| SCHEMBL7991052 | 0.82 | MAPK8 (0.34) | LMNAPDE4ASCN9A | |
| SCHEMBL7977309 | 0.82 | PDE4A (0.52) | LMNAPDE4A | |
| SCHEMBL7987426 | 0.80 | PDE4A (0.65) | PDE4A | |
| SCHEMBL7977060 | 0.80 | HSPB1 (0.48) | LMNAALDH1A1NPSR1SMN1; SMN2GAA | |
| SCHEMBL7996011 | 0.78 | LMNA (0.41) | LMNAALDH1A1PDE4APDE4BPDE4D | |
| SCHEMBL7989179 | 0.72 | PDE4A (0.37) | LMNAPDE4ASCN9A | |
| SCHEMBL14691446 | 0.71 | TTR (0.51) | LMNAALDH1A1PDE4APDE4BPDE4D | |
| SCHEMBL7994597 | 0.71 | LMNA (0.43) | LMNAPDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |