Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961372 | 0.83 | NPC1 (0.62) | SMN1; SMN2NPC1RECQLRAB9ANPSR1 | |
| SCHEMBL7974350 | 0.81 | NPC1 (0.46) | SMN1; SMN2NPC1RECQLRAB9AHRH3 | |
| SCHEMBL7977081 | 0.80 | HRH3 (0.49) | SMN1; SMN2NPC1RECQLRAB9AHRH3 | |
| SCHEMBL4376053 | 0.80 | HRH3 (0.49) | SMN1; SMN2NPC1RECQLRAB9AHRH3 | |
| SCHEMBL7961411 | 0.79 | CHRNB2 (0.52) | SMN1; SMN2L3MBTL1NPC1RECQLRAB9A | |
| SCHEMBL4376634 | 0.79 | NPC1 (0.47) | SMN1; SMN2NPC1RECQLRAB9AHRH3 | |
| SCHEMBL4388838 | 0.78 | HRH3 (0.38) | SMN1; SMN2NPC1RECQLRAB9AHRH3 | |
| SCHEMBL7987181 | 0.78 | GAA (0.55) | SMN1; SMN2L3MBTL1HRH3ALDH1A1KDM4E | |
| SCHEMBL4381005 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL1NPC1RAB9ATDP1 | |
| SCHEMBL7988960 | 0.78 | HRH3 (0.39) | HRH3NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37303-E1 | Imidazole compounds and their therapeutic applications | INSTITUT NATIONAL DEL LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2001-07-31 | — | — | US | claimed |
| US-5708171-A | HISTAMINE H3-RECEPTOR ANTAGONIST | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-01-13 | — | — | US | claimed |
| US-RE37303-E1 | Imidazole compounds and their therapeutic applications | INSTITUT NATIONAL DEL LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2001-07-31 | — | — | US | disclosed |
| US-5708171-A | HISTAMINE H3-RECEPTOR ANTAGONIST | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-01-13 | — | — | US | disclosed |
| US-5559113-A | ANTAGONISTS TO HISTAMINE H3 RECEPTORS, SEDATIVES, ANTICONVULSANTS, ANTIULCER AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | 1996-09-24 | — | — | US | disclosed |