Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MPO | P05164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975380 | 0.91 | LMNA (0.47) | LMNASMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL7974397 | 0.89 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7963991 | 0.89 | LMNA (0.45) | LMNASMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL7974465 | 0.88 | LMNA (0.47) | LMNASMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL7964021 | 0.88 | LMNA (0.47) | LMNASMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL7977583 | 0.87 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL7977567 | 0.87 | LMNA (0.47) | LMNASMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL7975451 | 0.87 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL7974305 | 0.86 | MAPT (0.53) | LMNASMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL7980362 | 0.86 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2NPC1RAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |