⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12939836 | 0.80 | — | — | |
| SCHEMBL28869966 | 0.76 | NLRP3 (0.39) | — | |
| SCHEMBL112699 | 0.75 | FAAH (0.43) | — | |
| SCHEMBL20239403 | 0.74 | — | — | |
| SCHEMBL15200818 | 0.74 | CES1 (0.51) | — | |
| SCHEMBL19556315 | 0.73 | — | — | |
| SCHEMBL1838907 | 0.73 | — | — | |
| SCHEMBL8303534 | 0.73 | — | — | |
| SCHEMBL2317970 | 0.72 | CES1 (0.40) | — | |
| SCHEMBL22437008 | 0.71 | MAP4K4 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3623372-B1 | PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS | VALO HEALTH INC (US) | 2026-02-04 | — | — | EP | disclosed |
| US-12018030-B2 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors | VALO HEALTH, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| CN-117916237-A | Amino aryl integrin agonist compounds | 德克萨斯心脏研究所 | 2024-04-19 | — | — | CN | disclosed |
| EP-3623372-A1 | PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS | Forma Therapeutics, Inc. (US) | 2020-03-18 | — | — | EP | disclosed |
| EP-3240791-B1 | PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS | FORMA THERAPEUTICS INC (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-2935249-B1 | AUTOTAXIN INHIBITORS | NOVARTIS AG (CH) | 2018-12-12 | — | — | EP | disclosed |
| EP-2951174-B1 | AMINO-SUBSTITUTED ISOTHIAZOLES | Bayer Pharma AG (DE) | 2017-04-26 | — | — | EP | disclosed |
| EP-2935249-A2 | AUTOTAXIN INHIBITORS | Novartis AG (CH) | 2015-10-28 | — | — | EP | disclosed |
| CN-104086538-A | PI3K kinase inhibitor intermediate, and preparation method and application thereof | PHARMABLOCK NANJING R & D CO LTD | 2014-10-08 | — | — | CN | disclosed |
| WO-2014097151-A2 | AUTOTAXIN INHIBITORS | NOVARTIS AG (CH) | 2014-06-26 | — | — | WO | disclosed |
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |