Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430758 | 1.00 | NPC1 (0.49) | NPC1POLBF2ELANEALDH1A1 | |
| SCHEMBL8605725 | 0.79 | ELANE (0.41) | ELANEALDH1A1KMT2ATSHR | |
| SCHEMBL8605131 | 0.79 | ELANE (0.41) | ELANEALDH1A1KMT2ATSHR | |
| SCHEMBL7372508 | 0.79 | LMNA (0.43) | POLBALDH1A1HPGDGAAL3MBTL1 | |
| SCHEMBL6430759 | 0.78 | JAK2 (0.38) | ALDH1A1HPGDGAAHRH3KMT2A | |
| SCHEMBL7371447 | 0.74 | CA12 (0.36) | POLBELANEALDH1A1HSD17B10ALOX15 | |
| SCHEMBL7429786 | 0.72 | ELANE (0.43) | POLBELANEALDH1A1HSD17B10HPGD | |
| SCHEMBL6431725 | 0.71 | ELANE (0.57) | NPC1POLBF2ELANEALDH1A1 | |
| SCHEMBL10724841 | 0.71 | POLB (0.81) | NPC1POLBALDH1A1HPGDALOX15 | |
| SCHEMBL6431149 | 0.70 | ELANE (0.56) | NPC1POLBF2ELANEHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194569-B1 | REACTING AZETIDINE CARBOXAMIDE COMPOUND WITH PIPERAZINE COMPOUND IN PRESENCE OF AQUEOUS BASE AND PHASE TRANSFER CATALYST | DUPONT PHARMACEUTICALS COMPANY | 2001-02-27 | — | — | US | disclosed |