Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430758 | 0.78 | NPC1 (0.49) | KMT2AGAAHPGDHRH3ALDH1A1 | |
| SCHEMBL7977845 | 0.78 | NPC1 (0.49) | KMT2AGAAHPGDHRH3ALDH1A1 | |
| SCHEMBL6431732 | 0.75 | ELANE (0.44) | JAK2JAK1KMT2ACA1CA2 | |
| SCHEMBL8605131 | 0.75 | ELANE (0.41) | KMT2ACA1CA2LMNAALDH1A1 | |
| SCHEMBL8605725 | 0.75 | ELANE (0.41) | KMT2ACA1CA2LMNAALDH1A1 | |
| SCHEMBL7368461 | 0.75 | LMNA (0.43) | KMT2AGAAHPGDLMNAHRH3 | |
| SCHEMBL6434554 | 0.73 | ELANE (0.45) | JAK2JAK1KMT2ACA1CA2 | |
| SCHEMBL6431151 | 0.73 | ELANE (0.44) | JAK2JAK1KMT2ACA1CA2 | |
| SCHEMBL6433789 | 0.73 | ELANE (0.38) | JAK2JAK1KMT2ALMNAHRH3 | |
| SCHEMBL29050309 | 0.72 | ALDH1A1 (0.44) | KMT2ACA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927049-B1 | LABELLED ELASTASE INHIBITORS | AMERSHAM PLC (GB) | 2005-05-11 | — | — | EP | disclosed |
| US-6375926-B1 | HUMAN LEUCOCYTE ELASTASE (HLE) INHIBITOR LABELLED WITH A DETECTABLE MOIETY WHERE THE INHIBITOR IS SYNTHETIC AND THE DETECTABLE MOIETY IS CHOSEN FROM A RADIOACTIVE ISOTOPE, A PARAMAGNETIC ION, A RADIOPAQUE COMPOUND AND AN ULTRASOUND | AMERSHAM INTERNATIONAL PLC | 2002-04-23 | — | — | US | disclosed |
| EP-0927049-A2 | LABELLED ELASTASE INHIBITORS | AMERSHAM INTERNATIONAL plc (GB) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998010800-A2 | LABELLED ELASTASE INHIBITORS | AMERSHAM INTERNATIONAL PLC (GB) | 1998-03-19 | — | — | WO | disclosed |