Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | IDH2 | P48735 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017861 | 0.81 | ATM (0.57) | ATMKAT6AL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL5032650 | 0.81 | CYP19A1 (0.60) | TDP1IDH2CA1CA2CA9 | |
| SCHEMBL3013616 | 0.80 | CA1 (0.51) | CA1CA2CA9PNMTALDH1A1 | |
| SCHEMBL3528919 | 0.79 | CYP2C19 (0.57) | IDH2CA1CA2CA9ALDH1A1 | |
| SCHEMBL5320347 | 0.79 | ATM (0.66) | ATMKAT6AL3MBTL1TDP1PGR | |
| SCHEMBL15653259 | 0.78 | IDH2 (0.44) | TDP1IDH2PNMTMAPK1 | |
| SCHEMBL17838857 | 0.78 | HTR6 (0.49) | TDP1IDH2CA1CA2CA9 | |
| SCHEMBL17513498 | 0.78 | ATM (0.60) | ATMKAT6AL3MBTL1TDP1PGR | |
| SCHEMBL14920908 | 0.77 | KAT6A (0.48) | KAT6ATDP1IDH2PNMTMAPK1 | |
| SCHEMBL24496339 | 0.76 | IDH2 (0.46) | IDH2CA1CA2CA9PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| CN-1257481-A | Pyridine derivatives and pharmaceutical compositions containing them | ASTRA PHARMA PROD (GB) | 2000-06-21 | — | — | CN | disclosed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | disclosed |