Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976817 | 0.86 | HPGD (0.62) | EGFRPIK3CAPIK3CGERBB2HPGD | |
| SCHEMBL7980026 | 0.86 | EGFR (0.63) | EGFRERBB2KDR | |
| SCHEMBL7980190 | 0.80 | EGFR (0.60) | EGFRERBB2HPGDALDH1A1FLT1 | |
| SCHEMBL7979940 | 0.79 | EGFR (0.64) | EGFRERBB2HPGDALDH1A1KDM4E | |
| SCHEMBL7983292 | 0.77 | EGFR (0.67) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL7125492 | 0.76 | EGFR (0.70) | EGFRERBB2FLT1 | |
| SCHEMBL7125487 | 0.76 | EGFR (0.70) | EGFRERBB2FLT1 | |
| SCHEMBL4367861 | 0.74 | CLK4 (0.55) | HPGDALDH1A1LMNAUSP2CYP1A2 | |
| SCHEMBL3606262 | 0.73 | EGFR (0.73) | EGFRPIK3CAPIK3CGERBB2FLT1 | |
| SCHEMBL7980576 | 0.73 | EGFR (0.66) | EGFRPIK3CAPIK3CGERBB2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |