Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 13/20 | 0.48 |
| ▸ | HRH1 | P35367 | 13/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243633 | 0.82 | HRH2 (0.72) | HRH2HRH1HRH3 | |
| SCHEMBL7979288 | 0.76 | HRH2 (0.38) | HRH2HRH1HRH3DRD3 | |
| SCHEMBL7246172 | 0.75 | HRH2 (0.74) | HRH2HRH1HRH3 | |
| SCHEMBL7250277 | 0.72 | HRH2 (0.72) | HRH2HRH1HRH3 | |
| SCHEMBL25910102 | 0.69 | CHRM1 (0.44) | HRH2HRH1HRH3 | |
| SCHEMBL14148845 | 0.68 | — | — | |
| SCHEMBL11376987 | 0.68 | ITGB3 (0.46) | — | |
| SCHEMBL11381970 | 0.68 | ITGB3 (0.46) | — | |
| SCHEMBL7248835 | 0.67 | HRH2 (0.45) | HRH2HRH1HRH3DRD3MEN1 | |
| SCHEMBL7252070 | 0.67 | HRH2 (0.52) | HRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001066534-A2 | CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |