Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 8/20 | 0.38 |
| ▸ | HRH1 | P35367 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.30 |
| ▸ | GPR183 | P32249 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979285 | 0.76 | HRH2 (0.48) | HRH2HRH1HRH3DRD3 | |
| SCHEMBL7978323 | 0.76 | HRH2 (0.54) | HRH2HRH1HRH3 | |
| SCHEMBL7980024 | 0.74 | HRH2 (0.51) | HRH2HRH1HRH3 | |
| SCHEMBL7243633 | 0.72 | HRH2 (0.72) | HRH2HRH1HRH3 | |
| SCHEMBL7978201 | 0.69 | HRH2 (0.58) | HRH2HRH1 | |
| SCHEMBL25910102 | 0.67 | CHRM1 (0.44) | HRH2HRH1HRH3DPP7CHRM1 | |
| SCHEMBL14148845 | 0.67 | — | — | |
| SCHEMBL7246172 | 0.65 | HRH2 (0.74) | HRH2HRH1HRH3 | |
| SCHEMBL28132610 | 0.64 | DPP7 (0.49) | HRH2HRH1DPP7 | |
| SCHEMBL28132609 | 0.64 | DPP7 (0.49) | HRH2HRH1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001066534-A2 | CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |