Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28066796 | 0.88 | AKR1C3 (0.55) | AKR1C3L3MBTL1NR4A1MAPTGAA | |
| SCHEMBL109282 | 0.82 | TSHR (0.57) | AKR1C3MRGPRX4L3MBTL1HTTMAPT | |
| SCHEMBL2913778 | 0.81 | AKR1C3 (0.48) | AKR1C3L3MBTL1MAPTGAAALDH1A1 | |
| SCHEMBL19243893 | 0.80 | AKR1C3 (0.47) | AKR1C3L3MBTL1MAPTGAAALDH1A1 | |
| SCHEMBL11072642 | 0.80 | AKR1C3 (0.47) | AKR1C3L3MBTL1MAPTGAAALDH1A1 | |
| SCHEMBL49873 | 0.78 | KMT2A (0.65) | AKR1C3L3MBTL1NR4A1MAPTGAA | |
| SCHEMBL29434816 | 0.78 | KMT2A (0.65) | AKR1C3L3MBTL1NR4A1MAPTGAA | |
| SCHEMBL10828176 | 0.78 | AKR1C3 (0.44) | AKR1C3MRGPRX4L3MBTL1MAPTGAA | |
| SCHEMBL27347082 | 0.77 | AKR1C3 (0.57) | AKR1C3NR4A1MAPTGAAALDH1A1 | |
| SCHEMBL30403796 | 0.77 | TSHR (0.64) | AKR1C3L3MBTL1NR4A1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271261-B1 | CHEMOKINE MEDIATED DISEASES, BINDING INTERLEUKINS OR BETA-RECEPTORS AND ADMINISTERING TO MAMMALS | SMITHKLINE BEECHAM CORPORATION | 2001-08-07 | — | — | US | disclosed |