SCHEMBL2913778

SCHEMBL2913778

N#Cc1cccc(C(=O)c2ccccc2)c1C#N

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.48
NPSR1 Q6W5P4 2/20 0.47
GAA P10253 2/20 0.46
MAPT P10636 2/20 0.46
ALDH1A1 P00352 3/20 0.43
ATM Q13315 3/20 0.42
TDP1 Q9NUW8 2/20 0.42
HSP90AA1 P07900 1/20 0.42
PKM P14618 1/20 0.42
CCR6 P51684 1/20 0.42
TLR9 Q9NR96 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
POLB P06746 3/20 0.40
CNR2 P34972 1/20 0.40
CDC25B P30305 1/20 0.40
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28066796 0.89 AKR1C3 (0.55) AKR1C3NPSR1GAAMAPTALDH1A1
SCHEMBL11120196 0.87 POLB (0.38) NPSR1GAAALDH1A1POLBLMNA
SCHEMBL6276446 0.86 CES2 (0.48) NPSR1GAAMAPTALDH1A1ATM
SCHEMBL1200740 0.85 AKR1C3 (0.55) AKR1C3NPSR1GAAMAPTALDH1A1
SCHEMBL4851536 0.82 ALDH1A1 (0.44) GAAALDH1A1POLBLMNA
SCHEMBL27532725 0.81 AKR1C3 (0.47) AKR1C3NPSR1GAAMAPTALDH1A1
SCHEMBL17227262 0.81 MAPT (0.53) AKR1C3NPSR1GAAMAPTALDH1A1
SCHEMBL11072642 0.81 AKR1C3 (0.47) AKR1C3NPSR1GAAMAPTALDH1A1
SCHEMBL19243893 0.81 AKR1C3 (0.47) AKR1C3NPSR1GAAMAPTALDH1A1
SCHEMBL7979358 0.81 AKR1C3 (0.47) AKR1C3NPSR1GAAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11697709-B2 Poly(arylene ether) compositions and articles incorporating the same THE BOEING COMPANY (US) 2023-07-11 US claimed
US-20220106441-A1 POLY(ARYLENE ETHER) COMPOSITIONS AND ARTICLES INCORPORATING THE SAME U.S. GOVERNMENT, AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 2022-04-07 US claimed
CN-103242198-A Method for preparing letrozole impurity HARBIN PHARMACEUTICAL GROUP CO LTD GENERAL PHARMACEUTICAL FACTORY 2013-08-14 CN claimed
CN-115175951-B Resin composition, cured product, prepreg, metal foil-clad laminate, resin sheet, and printed wiring board 三菱瓦斯化学株式会社 2024-07-12 CN disclosed
CN-118251445-A Cyclic organosiloxane containing imide bond and polymerizable unsaturated bond and curable resin composition containing the same 信越化学工业株式会社 2024-06-25 CN disclosed
CN-118043384-A Prepreg, laminate and printed circuit board 三菱瓦斯化学株式会社 2024-05-14 CN disclosed
CN-112236464-B Resin composition, prepreg, metal foil-clad laminate, resin sheet, and printed wiring board 三菱瓦斯化学株式会社 2024-02-23 CN disclosed
CN-117500851-A Resin composition, resin sheet, multilayer printed wiring board, and semiconductor device 三菱瓦斯化学株式会社 2024-02-02 CN disclosed
CN-117500850-A Resin composition, resin sheet, multilayer printed wiring board, and semiconductor device 三菱瓦斯化学株式会社 2024-02-02 CN disclosed
CN-117355545-A Resin composition, resin sheet, multilayer printed wiring board, and semiconductor device 三菱瓦斯化学株式会社 2024-01-05 CN disclosed
CN-117222682-A Cured resin composition and cured product thereof 日本化药株式会社 2023-12-12 CN disclosed
CN-112209851-A Extraction method of 4, 4-dicyanobenzophenone 山东斯瑞药业有限公司 2021-01-12 CN disclosed
CN-108779330-B Resin composition, prepreg, metal foil-clad laminate, resin sheet, and printed wiring board 三菱瓦斯化学株式会社 2019-12-17 CN disclosed
CN-110483763-A One kind branching type o-phthalonitrile resin of based structures containing benzoyl and preparation method thereof UNIV DALIAN TECH 2019-11-22 CN disclosed
CN-108409604-A Preparation method of letrozole key intermediate 杭州中美华东制药有限公司 2018-08-17 CN disclosed
CN-105801501-A Preparation method of letrozole 浙江工业大学 2016-07-27 CN disclosed
CN-103242198-A Method for preparing letrozole impurity HARBIN PHARMACEUTICAL GROUP CO LTD GENERAL PHARMACEUTICAL FACTORY 2013-08-14 CN disclosed
EP-2212301-A1 AN IMPROVED PROCESS FOR PREPARATION OF LETROZOLE AND ITS INTERMEDIATES Fresenius Kabi Oncology Limited (IN) 2010-08-04 EP disclosed
WO-2009069140-A1 AN IMPROVED PROCESS FOR PREPARATION OF LETROZOLE AND ITS INTERMEDIATES DABUR PHARMA LIMITED (IN) 2009-06-04 WO disclosed
EP-0170590-A1 Precursors of copolyphthalocyanine imide networks, their preparation and networks derived therefrom CENTRE D'ETUDE DES MATERIAUX ORGANIQUES POUR TECHNOLOGIES AVANCEES (FR) 1986-02-05 EP disclosed