Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28232963 | 0.83 | MAPK1 (0.54) | MAPK1GAARXFP1SMN1; SMN2CYP1A2 | |
| SCHEMBL7981079 | 0.80 | PTGS1 (0.67) | MAPK1GAARXFP1SMN1; SMN2CYP1A2 | |
| SCHEMBL118200 | 0.78 | PTGS1 (0.65) | MAPK1GAARXFP1SMN1; SMN2CYP1A2 | |
| SCHEMBL23890512 | 0.77 | PTGS1 (0.50) | MAPK1GAAPTGS1PTGS2ALDH1A1 | |
| SCHEMBL3613601 | 0.75 | SLC2A2 (0.69) | MAPK1GAASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL21577704 | 0.74 | ALDH1A1 (0.53) | MAPK1GAARXFP1SMN1; SMN2CYP1A2 | |
| SCHEMBL7979452 | 0.74 | PTGS1 (0.49) | MAPK1GAARXFP1SMN1; SMN2CYP1A2 | |
| SCHEMBL2261118 | 0.73 | MAPK1 (0.49) | MAPK1GAARXFP1SMN1; SMN2CYP1A2 | |
| SCHEMBL19700530 | 0.73 | MAPK1 (0.75) | MAPK1GAARXFP1SMN1; SMN2CYP1A2 | |
| SCHEMBL12295364 | 0.73 | MAPK1 (0.75) | MAPK1GAARXFP1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174877-B1 | EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0876370-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025325-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |