Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297387 | 0.96 | LMNA (0.41) | MEN1KMT2ALMNAPOLBKDM4C | |
| SCHEMBL10354329 | 0.94 | LMNA (0.43) | MEN1KMT2ALMNAPOLBKDM4C | |
| SCHEMBL18609254 | 0.89 | LMNA (0.46) | MEN1KMT2ALMNAPOLBNPC1 | |
| SCHEMBL28015283 | 0.89 | LMNA (0.34) | LMNAPOLBALDH1A1 | |
| SCHEMBL436526 | 0.88 | TSHR (0.45) | MEN1KMT2ALMNAPOLBKDM4C | |
| SCHEMBL439061 | 0.88 | TSHR (0.45) | MEN1KMT2ALMNAPOLBKDM4C | |
| SCHEMBL436527 | 0.88 | TSHR (0.45) | MEN1KMT2ALMNAPOLBKDM4C | |
| SCHEMBL12574578 | 0.88 | TSHR (0.45) | MEN1KMT2ALMNAPOLBKDM4C | |
| SCHEMBL19297378 | 0.86 | MEN1 (0.35) | MEN1KMT2ALMNAPOLBKDM4C | |
| SCHEMBL23061526 | 0.83 | TSHR (0.42) | MEN1KMT2ALMNAPOLBKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174877-B1 | EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0876370-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025325-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |