Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTH | P32929 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979663 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2ADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL7256704 | 0.76 | ADRA2A (0.49) | SMN1; SMN2ADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL7256700 | 0.76 | ADRA2A (0.49) | SMN1; SMN2ADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL3287572 | 0.76 | SMN1; SMN2 (0.69) | SMN1; SMN2NOS3NOS1ALDH1A1MAPT | |
| SCHEMBL3287569 | 0.76 | SMN1; SMN2 (0.69) | SMN1; SMN2NOS3NOS1ALDH1A1MAPT | |
| SCHEMBL13325330 | 0.76 | SMN1; SMN2 (0.69) | SMN1; SMN2NOS3NOS1ALDH1A1MAPT | |
| SCHEMBL10725133 | 0.75 | P2RX7 (0.49) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10725136 | 0.75 | P2RX7 (0.49) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7978023 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2NOS3NOS1NOS2ALDH1A1 | |
| SCHEMBL1309528 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2NOS3NOS1NOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255323-B1 | Cyanoguanidine compounds | SHIONOGI BIORESEARCH CORP. | 2001-07-03 | — | — | US | disclosed |
| WO-2000061561-A1 | CYANOGUANIDINE COMPOUNDS | SHIONOGI BIORESEARCH CORP. (US) | 2000-10-19 | — | — | WO | disclosed |