SCHEMBL7979856

SCHEMBL7979856

CC(=O)SCCc1csc(N)n1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.51
GABRA5 P31644 1/20 0.51
GABRB2 P47870 1/20 0.51
NOS1 P29475 2/20 0.45
SMN1; SMN2 Q16637 5/20 0.42
ALDH1A1 P00352 4/20 0.41
ATM Q13315 1/20 0.41
AOC3 Q16853 2/20 0.40
RAB9A P51151 4/20 0.40
NPC1 O15118 3/20 0.39
MAPT P10636 3/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3539057 0.74 SMN1; SMN2 (0.52) HSD17B10GABRA5GABRB2NOS1SMN1; SMN2
SCHEMBL11926737 0.74 HSD17B10 (0.70) HSD17B10GABRA5GABRB2NOS1SMN1; SMN2
Acetamide SCHEMBL9942181 0.73 GABRA5 (0.50) HSD17B10GABRA5GABRB2NOS1SMN1; SMN2
SCHEMBL307817 0.73
SCHEMBL2655261 0.73 GABRA5 (0.68) HSD17B10GABRA5GABRB2NOS1SMN1; SMN2
Acetic Acid SCHEMBL1340575 0.73 HSD17B10 (0.62) HSD17B10GABRA5GABRB2NOS1SMN1; SMN2
Acetic Acid SCHEMBL4983698 0.73 HSD17B10 (0.62) HSD17B10GABRA5GABRB2NOS1SMN1; SMN2
SCHEMBL7980749 0.72 NOS2 (0.42) NOS1
SCHEMBL9271595 0.72 GABRA5 (0.49) HSD17B10GABRA5GABRB2NOS1SMN1; SMN2
Acetic Acid SCHEMBL27742442 0.71 HSD17B10 (0.89) HSD17B10GABRA5GABRB2NOS1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6174877-B1 EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-16 US disclosed
EP-0876370-A1 CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1998-11-11 EP disclosed
WO-1997025325-A1 CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-07-17 WO disclosed