Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983616 | 0.95 | LCK (0.51) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7983212 | 0.92 | LCK (0.60) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7983677 | 0.91 | FGFR1 (0.50) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7983651 | 0.87 | LCK (0.59) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7987033 | 0.82 | LCK (0.49) | LCKFGFR1SRCL3MBTL1KDR | |
| SCHEMBL7982995 | 0.82 | LCK (0.47) | LCKFGFR1SRCKDR | |
| SCHEMBL7987540 | 0.81 | LCK (0.46) | LCKFGFR1SRCKDR | |
| SCHEMBL7969619 | 0.81 | LCK (0.37) | LCK | |
| SCHEMBL7979832 | 0.81 | LCK (0.49) | LCKFGFR1SRCFGFR2KDR | |
| SCHEMBL7969694 | 0.80 | LCK (0.38) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |