Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982995 | 0.97 | LCK (0.47) | LCKFGFR1KDRMAP4K4WEE1 | |
| SCHEMBL7987540 | 0.97 | LCK (0.46) | LCKFGFR1KDRMAP4K4WEE1 | |
| SCHEMBL7979832 | 0.95 | LCK (0.49) | LCKFGFR1KDRSRC | |
| SCHEMBL7979958 | 0.86 | LCK (0.56) | LCK | |
| SCHEMBL7983677 | 0.85 | FGFR1 (0.50) | LCKFGFR1KDRSRC | |
| SCHEMBL7969694 | 0.83 | LCK (0.38) | LCKCDK9CCNT1 | |
| SCHEMBL7980019 | 0.82 | LCK (0.52) | LCKFGFR1KDRSRCL3MBTL1 | |
| SCHEMBL7969619 | 0.82 | LCK (0.37) | LCKCDK9CCNT1 | |
| SCHEMBL7983616 | 0.80 | LCK (0.51) | LCKFGFR1SRCKDM4EL3MBTL1 | |
| SCHEMBL7970506 | 0.80 | RAD52 (0.39) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |