Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5074696 | 0.92 | KDM4E (0.59) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL2953028 | 0.84 | KDM4E (0.89) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL27289111 | 0.82 | NPC1 (0.56) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL1605174 | 0.81 | KDM4E (0.74) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL30692373 | 0.79 | ALDH1A1 (0.56) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL30692372 | 0.79 | ALDH1A1 (0.56) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL7981029 | 0.79 | NPC1 (0.64) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL1663955 | 0.79 | KDM4E (0.71) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL6996148 | 0.79 | KMT2A (0.56) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL214477 | 0.78 | KDM4E (0.80) | KDM4ESMN1; SMN2NPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |