Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 1.00 |
| ▸ | PRKACA | P17612 | 6/20 | 1.00 |
| ▸ | PRKACG | P22612 | 6/20 | 1.00 |
| ▸ | PRKACB | P22694 | 6/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980809 | 0.81 | SRC (1.00) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7984116 | 0.71 | SRC (0.55) | SRCPRKACAPRKACGPRKACBPIK3R1 | |
| SCHEMBL9367998 | 0.70 | SRC (0.53) | SRCPRKACAPRKACGPRKACBPIK3R1 | |
| SCHEMBL7981609 | 0.69 | SRC (1.00) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL23555526 | 0.64 | SRC (0.47) | SRCPRKACAPRKACGPRKACBPIK3R1 | |
| SCHEMBL7981575 | 0.64 | SRC (0.57) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7980243 | 0.64 | SRC (1.00) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL23555539 | 0.63 | MEN1 (0.47) | SRCPRKACAPRKACGPRKACBPIK3R1 | |
| SCHEMBL5795289 | 0.63 | KCNJ1 (0.46) | SRCPRKACAPRKACGPRKACBCYP19A1 | |
| SCHEMBL7981658 | 0.63 | SRC (1.00) | SRCPRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |