Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | PRKACG | P22612 | 1/20 | 0.53 |
| ▸ | PRKACB | P22694 | 1/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 3/20 | 0.34 |
| ▸ | FNTB | P49356 | 3/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984116 | 0.83 | SRC (0.55) | SRCPRKACAPRKACGPRKACBPIK3R1 | |
| SCHEMBL7980223 | 0.70 | SRC (1.00) | SRCPRKACAPRKACGPRKACBPIK3R1 | |
| SCHEMBL7981528 | 0.68 | SRC (0.52) | SRCPRKACAPRKACGPRKACBPIK3R1 | |
| SCHEMBL944720 | 0.62 | TRPV4 (0.53) | DRD4MAPTTDP1LMNASMN1; SMN2 | |
| SCHEMBL29710928 | 0.62 | TRPV4 (0.56) | DRD4LMNATSHRTRPV4PDE5A | |
| SCHEMBL523892 | 0.61 | TRPV4 (0.50) | LMNATSHRSMN1; SMN2TRPV4KDM4E | |
| SCHEMBL1402437 | 0.60 | TRPV4 (0.61) | DRD4MAPTSMN1; SMN2TRPV4KDM4E | |
| SCHEMBL22465375 | 0.59 | ALOX5AP (0.49) | MAPTSMN1; SMN2FNTAFNTBPGGT1B | |
| SCHEMBL28048048 | 0.58 | KDM4E (0.43) | MAPTLMNATSHRSMN1; SMN2TRPV4 | |
| SCHEMBL12187513 | 0.57 | LMNA (0.63) | MAPTTDP1LMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |