Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.52 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982616 | 0.89 | KDR (0.56) | SIRT2KDRFLT1FLT4NPC1 | |
| SCHEMBL7980188 | 0.87 | NTRK1 (0.48) | ABCB1NPC1MEN1ALDH1A1KMT2A | |
| SCHEMBL7744167 | 0.85 | HDAC1 (0.53) | SIRT2KDRFLT1FLT4HDAC1 | |
| SCHEMBL7969453 | 0.84 | HPGD (0.46) | SIRT2KDRFLT1FLT4RAB9A | |
| SCHEMBL7744170 | 0.82 | F2 (0.45) | KDRFLT1FLT4HDAC1ABCB1 | |
| SCHEMBL7744075 | 0.78 | MAPT (0.53) | HDAC1ABCB1RAB9AMEN1ALDH1A1 | |
| SCHEMBL7979621 | 0.77 | KDR (0.50) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7980184 | 0.77 | S1PR1 (0.45) | KDRFLT1FLT4HDAC1ABCB1 | |
| SCHEMBL7983601 | 0.76 | KDR (0.53) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7980821 | 0.76 | KDR (0.54) | KDRFLT1FLT4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |