Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981666 | 0.89 | KDR (0.46) | HPGDKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL7982616 | 0.87 | KDR (0.56) | RAB9AKDRFLT1FLT4ABL1 | |
| SCHEMBL7744651 | 0.86 | HPGD (0.51) | HPGDKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL7980265 | 0.84 | SIRT2 (0.52) | ALDH1A1RAB9ASMN1; SMN2KDRFLT1 | |
| SCHEMBL7744655 | 0.83 | HPGD (0.50) | HPGDKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL7981663 | 0.82 | KDR (0.50) | HPGDKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL7744758 | 0.78 | ALDH1A1 (0.46) | HPGDKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL7739022 | 0.77 | KDR (0.54) | HPGDKDM4EALDH1A1HSD17B10RAB9A | |
| SCHEMBL7744763 | 0.77 | KDM4E (0.46) | HPGDKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL7979621 | 0.75 | KDR (0.50) | KDM4EALDH1A1RAB9ASMN1; SMN2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |