Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982493 | 1.00 | CYP11B2 (0.39) | CYP11B2CYP11B1PGK1PTAFRAR | |
| SCHEMBL7976683 | 0.91 | CYP19A1 (0.42) | CYP11B2CYP11B1PTAFRCYP19A1PPARG | |
| SCHEMBL7976679 | 0.91 | CYP19A1 (0.42) | CYP11B2CYP11B1PTAFRCYP19A1PPARG | |
| SCHEMBL8020645 | 0.91 | CYP19A1 (0.42) | CYP11B2CYP11B1PTAFRCYP19A1PPARG | |
| SCHEMBL7982720 | 0.90 | PTAFR (0.38) | PTAFRARCYP19A1PPARGNCOA2 | |
| SCHEMBL7982723 | 0.90 | PTAFR (0.38) | PTAFRARCYP19A1PPARGNCOA2 | |
| SCHEMBL7979898 | 0.89 | PGK1 (0.39) | CYP11B2CYP11B1PGK1PTAFRSLC22A12 | |
| SCHEMBL7979900 | 0.89 | PGK1 (0.39) | CYP11B2CYP11B1PGK1PTAFRSLC22A12 | |
| SCHEMBL7980330 | 0.89 | CYP11B1 (0.47) | CYP11B2CYP11B1 | |
| SCHEMBL7980327 | 0.89 | CYP11B1 (0.47) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |