Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10741325 | 0.84 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNATDP1NPSR1 | |
| SCHEMBL7984053 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNATDP1NPSR1 | |
| SCHEMBL7980336 | 0.80 | HTT (0.51) | ALDH1A1MAPTLMNATDP1NPSR1 | |
| SCHEMBL7970089 | 0.78 | HTT (0.53) | ALDH1A1MAPTLMNASMN1; SMN2GAA | |
| SCHEMBL25207816 | 0.75 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNATDP1NPSR1 | |
| SCHEMBL2333730 | 0.74 | HTT (0.59) | ALDH1A1MAPTLMNATDP1NPSR1 | |
| SCHEMBL15808259 | 0.73 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNATDP1NPSR1 | |
| SCHEMBL5242387 | 0.72 | MAPT (0.53) | ALDH1A1MAPTLMNATDP1MEN1 | |
| SCHEMBL10500707 | 0.72 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNATDP1NPSR1 | |
| SCHEMBL28483458 | 0.72 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |