Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10459766 | 0.79 | HTT (0.56) | HTTMAPTSLC10A2TUBB4ATUBB | |
| SCHEMBL7980488 | 0.79 | HTT (0.60) | HTTMAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL5242387 | 0.78 | MAPT (0.53) | MAPTLMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7980415 | 0.78 | ALDH1A1 (0.47) | HTTMAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8288714 | 0.77 | PRKCZ (0.81) | MAPTPRKCZALDH1A1HPGD | |
| SCHEMBL4823776 | 0.77 | MAPT (0.49) | MAPTLMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7984003 | 0.77 | ERN1 (0.65) | HTTMAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL7983857 | 0.76 | HSD17B10 (0.47) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7222505 | 0.76 | MAPT (0.64) | HTTMAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL10741154 | 0.76 | MAPT (0.49) | MAPTPRKCZLMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |