Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GBA1 | P04062 | 1/20 | 0.57 |
| ▸ | PNLIP | P16233 | 1/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814952 | 0.92 | PNLIP (0.64) | KMT2AMEN1POLBMAPTHTT | |
| SCHEMBL6815607 | 0.89 | PNLIP (0.54) | KMT2AMEN1POLBMAPTHTT | |
| SCHEMBL6816221 | 0.88 | MAPT (0.58) | KMT2AMEN1POLBMAPTHTT | |
| SCHEMBL12010969 | 0.87 | KMT2A (0.78) | KMT2AMEN1POLBMAPTHTT | |
| SCHEMBL6811335 | 0.85 | KMT2A (0.59) | KMT2AMEN1POLBMAPTHTT | |
| SCHEMBL6815152 | 0.84 | KDM4E (0.55) | KMT2AMEN1MAPTHTTALDH1A1 | |
| SCHEMBL7981088 | 0.83 | KMT2A (0.69) | KMT2AMEN1POLBMAPTHTT | |
| SCHEMBL6816227 | 0.82 | ALDH1A1 (0.52) | KMT2APOLBMAPTHTTALDH1A1 | |
| SCHEMBL6815776 | 0.81 | MEN1 (0.62) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL6815573 | 0.81 | MAPT (0.62) | KMT2AMEN1POLBMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271236-B1 | PHENYL UREAS/THIOUREAS AS INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE ENZYME, USEFUL IN TREATING HUMAN CYTOMEGALOVIRUS, HERPES SIMPLEX VIRUSES, EPSTEIN-BARR VIRUS, AND VARICELLA-ZOSTER VIRUS | WYETH | 2001-08-07 | — | — | US | disclosed |