Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.50 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981203 | 0.83 | LMNA (0.57) | KDRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL6815777 | 0.82 | KDR (0.61) | KDRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL4555026 | 0.81 | LMNA (0.75) | KDRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL6815840 | 0.79 | GRM4 (0.57) | KDRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL7989797 | 0.78 | KMT2A (0.76) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL4555072 | 0.77 | LMNA (0.69) | KDRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL6815322 | 0.76 | LMNA (0.65) | KDRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL6815784 | 0.76 | LMNA (0.64) | KDRLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL5950186 | 0.76 | KDR (0.60) | MAPK14KDRALDH1A1KMT2AMEN1 | |
| SCHEMBL4555515 | 0.76 | LMNA (0.68) | KDRLMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271236-B1 | PHENYL UREAS/THIOUREAS AS INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE ENZYME, USEFUL IN TREATING HUMAN CYTOMEGALOVIRUS, HERPES SIMPLEX VIRUSES, EPSTEIN-BARR VIRUS, AND VARICELLA-ZOSTER VIRUS | WYETH | 2001-08-07 | — | — | US | disclosed |