Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.41 |
| ▸ | HTR2C | P28335 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793620 | 0.87 | CYP17A1 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL794032 | 0.84 | CYP11B2 (0.44) | CYP11B2CYP11B1HTR2CCYP1A2HTR2B | |
| SCHEMBL15467173 | 0.82 | CYP11B2 (0.52) | CYP11B2CYP11B1HTR2CHTR2BP2RX7 | |
| SCHEMBL15471852 | 0.81 | CYP11B2 (0.46) | CYP11B2CYP11B1HTR2CCYP1A2HTR2B | |
| SCHEMBL807910 | 0.80 | CYP11B2 (0.59) | CYP11B2CYP11B1HTR2CHTR2BP2RX7 | |
| SCHEMBL793750 | 0.78 | CYP11B2 (0.46) | CYP11B2CYP11B1HTR2CHTR2BP2RX7 | |
| SCHEMBL807794 | 0.78 | KMT2A (0.51) | CYP11B2CYP11B1HTR2CCYP1A2HTR2B | |
| SCHEMBL798105 | 0.75 | CYP11B2 (0.43) | CYP11B2CYP11B1HTR2CCYP1A2HTR2B | |
| SCHEMBL15471847 | 0.75 | CYP11B2 (0.43) | CYP11B2CYP11B1HTR2CHTR2BP2RX7 | |
| SCHEMBL12467032 | 0.75 | CYP11B2 (0.52) | CYP11B2CYP11B1P2RX7PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946260-B2 | 17α-hydroxylase/C17,20-lyase inhibitors | NOVARTIS AG (CH) | 2015-02-03 | — | — | US | disclosed |
| US-20140045872-A1 | 17a-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2014-02-13 | — | — | US | disclosed |
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045872-A1 | 17a-HYDROXYLASE/C17,20-LYASE INHIBITORS | CYP17A1, CYP21A2, HSD17B1 | CYP11B2 30/4885CYP11B1 18/4885HTR2C 2446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.