Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.73 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4108434 | 0.86 | NOTUM (0.55) | NOTUMCNR2GAAHTTNPC1 | |
| SCHEMBL30930563 | 0.85 | NOTUM (0.71) | NOTUMCNR2CDK4CCND1PDK1 | |
| SCHEMBL31465710 | 0.85 | NOTUM (0.71) | NOTUMCNR2CDK4CCND1PDK1 | |
| SCHEMBL2205988 | 0.85 | NOTUM (1.00) | NOTUMCNR2CDK4CCND1CYP11B2 | |
| SCHEMBL26691279 | 0.85 | NOTUM (0.71) | NOTUMCNR2CDK4CCND1PDK1 | |
| SCHEMBL7814158 | 0.82 | NOTUM (0.65) | NOTUMCNR2GAAALDH1A1KDM4E | |
| SCHEMBL853846 | 0.79 | PDK1 (0.50) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL3971068 | 0.79 | NOTUM (0.73) | NOTUMCDK4CCND1HDAC1HDAC6 | |
| SCHEMBL288802 | 0.79 | SLC22A12 (0.59) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL15690093 | 0.79 | NOTUM (0.49) | NOTUMCNR2CYP11B2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274594-B1 | ANTICONVULSANTS, ANALGESICS; NERUOPATHIC, CANCER AND DENTAL PAIN; | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-14 | — | — | US | claimed |
| US-9546162-B2 | Compounds and methods for skin repair | ALLERGAN, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| EP-3049392-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN, INC. (US) | 2016-08-03 | — | — | EP | disclosed |
| WO-2015048553-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN, INC. (US) | 2015-04-02 | — | — | WO | disclosed |
| US-20150094330-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN INC (US) | 2015-04-02 | — | — | US | disclosed |
| US-6274594-B1 | ANTICONVULSANTS, ANALGESICS; NERUOPATHIC, CANCER AND DENTAL PAIN; | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094330-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | PTGER4, LTB4R2, LTB4R | NOTUM 1966/4885CNR2 97/4885CDK4 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.