Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 1.00 |
| ▸ | PRKACA | P17612 | 7/20 | 1.00 |
| ▸ | PRKACG | P22612 | 7/20 | 1.00 |
| ▸ | PRKACB | P22694 | 7/20 | 1.00 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | GLI1 | P08151 | 1/20 | 0.40 |
| ▸ | GLI2 | P10070 | 1/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980308 | 0.68 | SRC (1.00) | SRCPRKACAPRKACGPRKACBAR | |
| SCHEMBL3883791 | 0.66 | SRC (1.00) | SRCPRKACAPRKACGPRKACBAR | |
| SCHEMBL29493185 | 0.66 | SRC (0.49) | SRCPRKACAPRKACGPRKACBAR | |
| SCHEMBL22738348 | 0.63 | SRC (0.46) | SRCPRKACAPRKACGPRKACBGPR35 | |
| SCHEMBL12666326 | 0.61 | AR (0.54) | SRCPRKACAPRKACGPRKACBAR | |
| SCHEMBL8140912 | 0.60 | SRC (0.58) | SRCPRKACAPRKACGPRKACBGPR35 | |
| SCHEMBL29878415 | 0.60 | ALOX15 (0.46) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL67808 | 0.60 | ALOX15 (0.46) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL12067595 | 0.59 | SRC (0.56) | SRCPRKACAPRKACGPRKACBAR | |
| SCHEMBL18068460 | 0.59 | SRC (0.41) | SRCPRKACAPRKACGPRKACBGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |