Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815730 | 0.95 | NOX4 (0.45) | POLBNOX4HTR6PPARGPPARD | |
| SCHEMBL7980485 | 0.93 | NOX4 (0.44) | POLBNOX4HTR6PIK3R1PIK3CA | |
| SCHEMBL7969048 | 0.91 | HTR6 (0.43) | POLBNOX4HTR6TP53PPARG | |
| SCHEMBL7981880 | 0.89 | PPARG (0.47) | POLBNOX4HTR6AKR1C3AKR1C2 | |
| SCHEMBL7969050 | 0.88 | HTR6 (0.47) | POLBNOX4HTR6LMNAMAPT | |
| SCHEMBL7982037 | 0.82 | NOX4 (0.39) | POLBNOX4PIK3R1PIK3CAMAPT | |
| SCHEMBL7827050 | 0.80 | HTR6 (0.39) | POLBHTR6TP53LMNAMAPT | |
| SCHEMBL7811436 | 0.78 | NOX4 (0.49) | POLBNOX4PIK3R1PIK3CAMAPT | |
| SCHEMBL7812528 | 0.78 | PTGS1 (0.46) | POLBHTR6PTGS2PTGS1TP53 | |
| SCHEMBL7811492 | 0.73 | HTR6 (0.48) | HTR6TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180637-B1 | THERAPY FOR PARKINSON, ALZHEIMER DISEASE | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2001-01-30 | — | — | US | claimed |
| US-6180637-B1 | THERAPY FOR PARKINSON, ALZHEIMER DISEASE | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2001-01-30 | — | — | US | disclosed |