Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982204 | 0.87 | NOTUM (0.40) | NOTUMHSD11B1 | |
| SCHEMBL1417775 | 0.86 | NOTUM (0.41) | NOTUMHSD11B1 | |
| SCHEMBL12677424 | 0.81 | HSD11B1 (0.47) | HSD11B2HSD11B1 | |
| SCHEMBL2056587 | 0.81 | HSD11B1 (0.51) | NOTUMHSD11B2HSD11B1 | |
| SCHEMBL12677376 | 0.76 | HSD11B1 (0.50) | HSD11B2HSD11B1 | |
| SCHEMBL7968569 | 0.75 | HSD11B1 (0.46) | HSD11B2HSD11B1 | |
| SCHEMBL7981732 | 0.74 | HSD11B1 (0.47) | HSD11B2HSD11B1 | |
| SCHEMBL7980060 | 0.74 | HSD11B1 (0.45) | HSD11B2HSD11B1 | |
| SCHEMBL7989328 | 0.72 | HSD11B1 (0.39) | HSD11B2HSD11B1 | |
| SCHEMBL7989134 | 0.72 | HSD11B1 (0.46) | HSD11B2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298747-A1 | TRIAZOLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2011-03-23 | — | — | EP | disclosed |
| WO-2010001946-A1 | TRIAZOLE DERIVATIVE OR SALT THEREOF | アステラス製薬株式会社 (JP) | 2010-01-07 | — | — | WO | disclosed |