Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.43 |
| ▸ | HRH2 | P25021 | 7/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | ATF4 | P18848 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966044 | 0.81 | HRH2 (0.59) | HRH1HRH2HRH3DRD2 | |
| SCHEMBL7966024 | 0.81 | HRH2 (0.59) | HRH1HRH2HRH3DRD2 | |
| SCHEMBL7966219 | 0.80 | HRH2 (0.63) | HRH1HRH2HRH3DRD2 | |
| SCHEMBL7979509 | 0.80 | HRH2 (0.63) | HRH1HRH2HRH3DRD2 | |
| SCHEMBL7245015 | 0.80 | HRH3 (0.59) | HRH3 | |
| SCHEMBL7982418 | 0.77 | HRH3 (0.47) | HRH1HRH2HRH3GPR119 | |
| SCHEMBL14367415 | 0.73 | ATF4 (0.48) | HRH1HRH3ATF4MAOBDRD2 | |
| SCHEMBL7246306 | 0.72 | GPR119 (0.49) | HRH1HRH2HRH3GPR119MAOB | |
| SCHEMBL7246309 | 0.72 | GPR119 (0.49) | HRH1HRH2HRH3GPR119MAOB | |
| Hydrochloric Acid SCHEMBL1714803 | 0.72 | ATF4 (0.47) | HRH1HRH3ATF4MAOBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001066534-A2 | CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | claimed |