Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.63 |
| ▸ | KDR | P35968 | 20/20 | 0.63 |
| ▸ | IGF1R | P08069 | 19/20 | 0.63 |
| ▸ | MST1R | Q04912 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798286 | 0.91 | MET (0.66) | METKDRIGF1RMST1R | |
| SCHEMBL798287 | 0.89 | MET (0.64) | METKDRIGF1RMST1R | |
| SCHEMBL798290 | 0.88 | MET (0.60) | METKDRIGF1RMST1R | |
| SCHEMBL13467640 | 0.87 | MET (0.59) | METKDRIGF1RMST1R | |
| SCHEMBL198266 | 0.86 | MET (0.80) | METKDRIGF1R | |
| SCHEMBL2742742 | 0.84 | MET (0.49) | METKDRIGF1RMST1R | |
| SCHEMBL198617 | 0.81 | MET (0.73) | METKDRIGF1R | |
| SCHEMBL798302 | 0.79 | MET (0.60) | METKDRIGF1RMST1R | |
| SCHEMBL783635 | 0.79 | MET (0.84) | METKDRIGF1RMST1R | |
| SCHEMBL200475 | 0.78 | MET (0.77) | METKDRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881976-B1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC (US) | 2012-10-17 | — | — | EP | disclosed |
| US-20120070413-A1 | METHOD OF TREATING CANCER WITH SUBSTITUTED AMIDE DERIVATIVES | KIM TAE-SEONG (US) | 2012-03-22 | — | — | US | disclosed |
| US-8088794-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20080312232-A1 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312232-A1 | Substituted amide derivatives and methods of use | HGF, HGFAC, MET | MET 3/4885KDR 200/4885IGF1R 57/4885 |
| US-20120070413-A1 | METHOD OF TREATING CANCER WITH SUBSTITUTED AMIDE DERIVATIVES | HGF, HGFAC, MET | MET 3/4885KDR 304/4885IGF1R 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.