SCHEMBL7983108

SCHEMBL7983108

CC1(C)CN(C(=O)O)c2ccc(F)cc21

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 3/20 0.47
HDAC1 Q13547 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
AMPD2 Q01433 2/20 0.42
SLC6A2 P23975 2/20 0.42
SLC6A4 P31645 2/20 0.42
CNR2 P34972 1/20 0.40
AKR1B1 P15121 1/20 0.38
ANPEP P15144 3/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
CTSS P25774 4/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3025336 0.89 NOTUM (0.62) NOTUMHDAC1HDAC6AMPD2SLC6A2
SCHEMBL16600254 0.88 NOTUM (0.45) NOTUMHDAC1HDAC6AMPD2SLC6A2
SCHEMBL31378017 0.86 AMPD2 (0.41) NOTUMHDAC1HDAC6AMPD2CNR2
SCHEMBL28743780 0.78 AMPD2 (0.37) NOTUMHDAC1HDAC6AMPD2PTGDR2
SCHEMBL31378009 0.76 AMPD2 (0.41) NOTUMAMPD2SLC6A2SLC6A4AKR1B1
SCHEMBL7984446 0.76 NOTUM (0.77) NOTUMSLC6A2SLC6A4CNR2MEN1
SCHEMBL9917021 0.76 SLC6A2 (0.42) NOTUMHDAC1HDAC6SLC6A2SLC6A4
SCHEMBL27636160 0.76 SLC6A2 (0.49) HDAC1HDAC6SLC6A2SLC6A4CTSS
SCHEMBL2264163 0.76 HDAC1 (0.39) NOTUMHDAC1HDAC6AMPD2
SCHEMBL2261573 0.76 NOTUM (0.40) NOTUMHDAC1HDAC6AMPD2SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6274594-B1 ANTICONVULSANTS, ANALGESICS; NERUOPATHIC, CANCER AND DENTAL PAIN; SMITHKLINE BEECHAM P.L.C. (GB) 2001-08-14 US claimed
EP-1032570-A1 ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE SMITHKLINE BEECHAM PLC (GB) 2000-09-06 EP claimed
WO-1999025709-A1 ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE SMITHKLINE BEECHAM P.L.C. (GB) 1999-05-27 WO claimed
US-6274594-B1 ANTICONVULSANTS, ANALGESICS; NERUOPATHIC, CANCER AND DENTAL PAIN; SMITHKLINE BEECHAM P.L.C. (GB) 2001-08-14 US disclosed
EP-1032570-A1 ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE SMITHKLINE BEECHAM PLC (GB) 2000-09-06 EP disclosed
WO-1999025709-A1 ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE SMITHKLINE BEECHAM P.L.C. (GB) 1999-05-27 WO disclosed