Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 7/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.46 |
| ▸ | HTR3B | O95264 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.46 |
| ▸ | SORD | Q00796 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8567570 | 0.83 | HTR3E (0.67) | MAPTTSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL7970020 | 0.79 | POLB (0.62) | MAPTHSD17B10KDM4EPOLBHPGD | |
| SCHEMBL7970011 | 0.77 | HTR3E (0.72) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL15800694 | 0.71 | PLD1 (0.73) | MAPTTSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL21353591 | 0.71 | — | — | |
| SCHEMBL29857922 | 0.71 | PLD1 (0.73) | MAPTTSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL7306002 | 0.70 | HTR1A (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1266147 | 0.68 | PLD1 (0.63) | MAPTTSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL30734132 | 0.66 | HRH4 (0.66) | MAPTHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL22796403 | 0.66 | HTR3E (0.68) | MAPTKDM4EHPGDHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |