Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27494891 | 0.84 | TP53 (0.33) | KDM4E | |
| SCHEMBL23135748 | 0.83 | GPR119 (0.50) | KDM4EPKMGPR119HPGDRECQL | |
| SCHEMBL7423554 | 0.82 | KDM4E (0.48) | KDM4EPKMGPR119HPGDRECQL | |
| SCHEMBL29190839 | 0.81 | KDM4E (0.47) | KDM4EPKMGPR119HPGDRECQL | |
| SCHEMBL1575491 | 0.79 | GPR119 (0.47) | KDM4EPKMGPR119HPGDRECQL | |
| SCHEMBL12082 | 0.79 | HPGD (0.55) | KDM4EPKMGPR119HPGDRECQL | |
| SCHEMBL24510146 | 0.78 | HPGD (0.48) | KDM4EPKMGPR119HPGDRECQL | |
| SCHEMBL13537861 | 0.78 | HPGD (0.44) | KDM4EPKMGPR119HPGDRECQL | |
| Ammonia Solution, Strong SCHEMBL7871661 | 0.77 | HPGD (0.54) | KDM4EPKMGPR119HPGDRECQL | |
| SCHEMBL8624104 | 0.77 | GPR119 (0.47) | KDM4EPKMGPR119HPGDRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |