SCHEMBL7983396

SCHEMBL7983396

Nc1nc(N)c(N)c(OCCc2ccccc2)n1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 2/20 0.58
CCNB1 P14635 2/20 0.58
CCNA2 P20248 2/20 0.58
CDK2 P24941 2/20 0.58
CCNA1 P78396 2/20 0.58
MPO P05164 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.56
CYP2D6 P10635 1/20 0.50
MGMT P16455 2/20 0.49
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
DHFR P00374 4/20 0.43
DCPS Q96C86 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3338311 0.83 MGMT (0.68) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL7988070 0.81 CDK2 (0.77) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL18072502 0.75 NUDT1 (0.53) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL16852229 0.74 MGMT (0.64) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL16464519 0.73 CDK1 (0.40) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL16462904 0.73 KMT2A (0.37) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL11699945 0.73 CDK1 (0.54) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL16828192 0.72 MGMT (0.54) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL5040455 0.72 ADORA1 (0.60) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL16463635 0.72 CCNA2 (0.41) CDK1CCNB1CCNA2CDK2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303618-B1 ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2001-10-16 US disclosed