SCHEMBL7988070

SCHEMBL7988070

Nc1nc(N)c(N=O)c(OCCc2ccccc2)n1

nearest known ligand 0.77

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 8/20 0.77
CCNA2 P20248 7/20 0.77
CCNA1 P78396 7/20 0.77
CDK1 P06493 7/20 0.77
CCNB1 P14635 6/20 0.77
MGMT P16455 4/20 0.77
MPO P05164 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.50
MEN1 O00255 1/20 0.48
CCNB2 O95067 1/20 0.48
MTOR P42345 1/20 0.48
KMT2A Q03164 1/20 0.48
ATR Q13535 1/20 0.48
CCNB3 Q8WWL7 1/20 0.48
CYP2D6 P10635 1/20 0.44
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
DCPS Q96C86 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2054835 0.87 MGMT (1.00) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL7983396 0.81 CDK1 (0.58) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL2056438 0.77 CCNA2 (0.67) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL16463323 0.76 CDK2 (0.66) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL8509225 0.76 MGMT (1.00) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL16465651 0.72 CDK2 (1.00) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL4454204 0.72 CDK2 (0.66) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL16463170 0.71 CDK2 (0.63) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL18072502 0.70 NUDT1 (0.53) CDK2CCNA2CCNA1CDK1CCNB1
SCHEMBL5040455 0.69 ADORA1 (0.60) CDK2CCNA2CCNA1CDK1CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303618-B1 ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2001-10-16 US disclosed