Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | C1R | P00736 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983501 | 0.80 | LCK (1.00) | LCKTP53ABCG2KMT2ASMN1; SMN2 | |
| SCHEMBL7979987 | 0.65 | LCK (0.58) | LCKTP53ABCG2SMN1; SMN2 | |
| SCHEMBL4036600 | 0.64 | LCK (0.73) | LCKTP53 | |
| SCHEMBL7970141 | 0.61 | LCK (0.56) | LCKTP53ABCG2SMN1; SMN2GSK3B | |
| SCHEMBL7969745 | 0.60 | LCK (0.80) | LCK | |
| SCHEMBL26486811 | 0.60 | ATM (0.79) | TP53KMT2ASMN1; SMN2 | |
| SCHEMBL7983647 | 0.60 | LCK (0.74) | LCKKMT2A | |
| SCHEMBL7981144 | 0.60 | LCK (0.74) | LCK | |
| SCHEMBL2819718 | 0.59 | IKBKB (0.69) | LCKTP53KMT2ASMN1; SMN2 | |
| SCHEMBL7983541 | 0.59 | LCK (0.77) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |