Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 10/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970141 | 0.79 | LCK (0.56) | LCKABCG2TP53HPGDHSD17B10 | |
| SCHEMBL7983481 | 0.73 | LCK (0.49) | LCKTP53HPGDHSD17B10LMNA | |
| SCHEMBL7987230 | 0.68 | LCK (1.00) | LCKTP53HPGDHSD17B10KDM4E | |
| SCHEMBL7983501 | 0.67 | LCK (1.00) | LCKABCG2TP53LMNASMN1; SMN2 | |
| SCHEMBL7969727 | 0.67 | LCK (0.67) | LCKTP53HPGDHSD17B10KDM4E | |
| SCHEMBL7983262 | 0.66 | LCK (0.41) | LCKABCG2TP53HPGDHSD17B10 | |
| SCHEMBL22649103 | 0.66 | ABCG2 (0.49) | LCKABCG2TP53HPGDLMNA | |
| SCHEMBL7983573 | 0.66 | LCK (0.43) | LCKTP53HPGDKDM4EALDH1A1 | |
| SCHEMBL28109995 | 0.66 | KDM4E (0.48) | LCKABCG2HSD17B10LMNAMAPK1 | |
| SCHEMBL7983496 | 0.65 | LCK (0.66) | LCKABCG2TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |