Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983496 | 0.80 | LCK (0.66) | LCKTP53GSK3BSMN1; SMN2ABCG2 | |
| SCHEMBL7969745 | 0.69 | LCK (0.80) | LCK | |
| SCHEMBL7983647 | 0.68 | LCK (0.74) | LCKMEN1KMT2A | |
| SCHEMBL4036600 | 0.68 | LCK (0.73) | LCKTP53 | |
| SCHEMBL7979987 | 0.67 | LCK (0.58) | LCKTP53LMNASMN1; SMN2ABCG2 | |
| SCHEMBL7981225 | 0.66 | LCK (0.74) | LCK | |
| SCHEMBL7983627 | 0.66 | LCK (0.76) | LCK | |
| SCHEMBL2819718 | 0.66 | IKBKB (0.69) | LCKTP53LMNASMN1; SMN2HIF1A | |
| SCHEMBL7970141 | 0.65 | LCK (0.56) | LCKTP53GSK3BLMNASMN1; SMN2 | |
| SCHEMBL3940988 | 0.64 | ALDH1A1 (0.50) | LCKTP53SMN1; SMN2MAPTABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |