Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | BCL9 | O00512 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982679 | 0.78 | GAA (0.39) | ALOX15KMT2ARAB9ABCL9CTNNB1 | |
| SCHEMBL7980862 | 0.78 | PTGS1 (0.47) | KMT2ARAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL2066827 | 0.74 | PDE4A (0.38) | PDE4ARAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL7980755 | 0.73 | MAPT (0.36) | ALOX15KMT2ARAB9ABCL9CTNNB1 | |
| SCHEMBL7982712 | 0.71 | BCL9 (0.34) | ALOX15KMT2ARAB9ABCL9CTNNB1 | |
| SCHEMBL7981083 | 0.71 | HRH4 (0.42) | ALOX15KMT2ARAB9ABCL9CTNNB1 | |
| SCHEMBL7983599 | 0.69 | PDE4A (0.47) | PDE4AALOX15KMT2AGAAKDM4E | |
| SCHEMBL17492364 | 0.69 | GAA (0.62) | PDE4AKMT2ARAB9AGAAKDM4E | |
| SCHEMBL7986875 | 0.69 | KDM4E (0.53) | KMT2ARAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL700968 | 0.68 | PDE4A (0.45) | PDE4AALOX15KMT2ARAB9ABCL9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174877-B1 | EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-16 | — | — | US | disclosed |