Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | GCGR | P47871 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27566563 | 0.93 | HPGD (0.47) | HPGDGCGRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7970370 | 0.90 | PDE4A (0.44) | HPGDALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL7983565 | 0.88 | MEN1 (0.50) | HPGDALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL8326204 | 0.88 | NPC1 (0.47) | HPGDALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL7980646 | 0.84 | NPY5R (0.50) | HPGDALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL28743198 | 0.84 | NR1H4 (0.46) | HPGDALDH1A1MAPTTEAD1TEAD4 | |
| SCHEMBL7987870 | 0.84 | HPGD (0.40) | HPGDALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL7984229 | 0.84 | PDE4A (0.46) | HPGDALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL3176719 | 0.84 | TEAD1 (0.53) | ALDH1A1MEN1KMT2AMAPTPDE7A | |
| SCHEMBL27517740 | 0.83 | HPGD (0.40) | HPGDALDH1A1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |