Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 1.00 |
| ▸ | PRKACA | P17612 | 6/20 | 0.53 |
| ▸ | PRKACG | P22612 | 6/20 | 0.53 |
| ▸ | PRKACB | P22694 | 6/20 | 0.53 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PARL | Q9H300 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987642 | 0.74 | SRC (0.65) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7980253 | 0.71 | SRC (0.55) | SRCNOD1PTGS2 | |
| SCHEMBL7988542 | 0.70 | SRC (1.00) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7987613 | 0.69 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7969684 | 0.69 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7987368 | 0.67 | SRC (1.00) | SRCPRKACAPRKACGPRKACBNOX4 | |
| SCHEMBL7980678 | 0.67 | SRC (1.00) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL5594350 | 0.64 | CA1 (0.55) | SRCNOD1PARL | |
| 4-Nitrocatechol SCHEMBL2977451 | 0.63 | GPR35 (0.60) | GAATHRBPTGS2 | |
| 4-Nitrocatechol SCHEMBL2977452 | 0.63 | GPR35 (0.60) | GAATHRBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |